Effects of cadmium ingestion in rats with opposite genetic predisposition to hypertension

Journal Article · Thu Feb 01 04:00:00 EST 1979 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.7928261· OSTI ID:5792954

Ohanian, E V; Iwai, J

This study was undertaken to explore the effects of chronic low-level cadmium ingestion in Dahl hypertension-resistant (R) and hypertension-sensitive (S) lines of rats. Groups of weanling female R and S rats were given 0 or 1 mg cadmium/l in drinking water and fed either a low salt (0.4% NaCl) or a high salt (4% NaCl) diet for 28 weeks. Cadmium produced hypertension associated with gross cardiac hypertrophy and mild to moderate renal vascular changes in S, but not in R, rats on a low salt diet. Cadmium enhanced the rate and degree of development of salt-induced hypertension without the hypercholesterolemia or renal vascular lesions normally observed in S rats on a high salt diet. Cadmium lowered circulating cholesterol levels in both lines on a low salt diet. Cadmium had no influence on growth, blood urea nitrogen concentration, plasma renin activity, tumor formation, or survivorship in R and S rats on either salt diet. This study indicates that the genetic composition is a critical determinant of the adverse effects of chronic low-level cadmium ingestion in rats. In addition to the experimental implications, these findings may have relevance to the problem of human essential hypertension.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 5792954
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 28; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

551000* -- Physiological Systems
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
AMIDES
ANIMAL GROWTH
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL VARIABILITY
BODY
CADMIUM
CARBONIC ACID DERIVATIVES
CARCINOGENESIS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
CHOLESTEROL
DIET
DISEASES
ELEMENTS
ENZYMES
FEMALES
GENETIC CONTROL
GROWTH
HALIDES
HALOGEN COMPOUNDS
HEART
HYDROLASES
HYDROXY COMPOUNDS
HYPERTENSION
HYPERTROPHY
INGESTION
INTAKE
KIDNEYS
MAMMALS
METALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PATHOLOGICAL CHANGES
PEPTIDE HYDROLASES
PEST CONTROL
RATS
RENIN
RESPONSE MODIFYING FACTORS
RODENTS
SODIUM CHLORIDES
SODIUM COMPOUNDS
STEROIDS
STEROLS
SURVIVAL TIME
SYMPTOMS
TOXICITY
UREA
VASCULAR DISEASES
VERTEBRATES