The effect dietary Cu intake on the development of hypertension in the Dahl-S rat

Journal Article · Thu Feb 09 04:00:00 EST 1989 · FASEB Journal (Federation of American Societies for Experimental Biology); (USA)

OSTI ID:6832884

Garrow, T; Metzler, G; Clegg, M S; Keen, C L ^[1]

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1. Univ. of California, Davis (USA)

It has been shown that hypertense Dahl-S rats are characterized by abnormal Cu metabolism. To test the idea that variable dietary Cu intake may influence the development of hypertension in these rats, Dahl salt-sensitive rats were fed ad libitum one of six diets in a 2x3 design. Diets contained 0.4% Na (normotensive; NT) or 8.0% Na (hypertense; HT), and 2, 12 or 50 ug Cu/g diet. Initial body weights and mean systolic blood pressures did not differ among groups. Rats were killed when mean systolic blood pressure was 190 mm Hg. Dietary Cu had no effect on development of hypertension among the high Na groups. Dietary Cu had no effect on final body weights; however, HT rats weighed less than NT rats and had cardio- and splenomegaly and low hematocrits. The rats fed the low Cu diets had lower levels of liver, heart and plasma Cu, and ceruloplasmin oxidase (CP) activity than the other groups. The HT groups had significant increase in plasma Cu and CP activity compared to their NT counterparts. The increase in plasma CP activity was related to the increase in blood pressure. Independent of dietary Cu, the HT groups also had significant reduction in plasma Zn and increases in hepatic metallothionein and plasma cholesterol compared to the NT groups. These results support the idea that hypertension has a marked effect on Cu metabolism. The influence of this effect on vascular pathology needs to be ascertained.

• OSTI ID: 6832884
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (USA), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (USA) Vol. 3:3; ISSN FAJOE; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CHOLESTEROL
COPPER
DIET
DIGESTIVE SYSTEM
DISEASES
ELEMENTS
ENZYMES
ETIOLOGY
GLANDS
HYDROXY COMPOUNDS
HYPERTENSION
LIVER
MATERIALS
METABOLISM
METALLOPROTEINS
METALLOTHIONEIN
METALS
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PROTEINS
STEROIDS
STEROLS
SYMPTOMS
TRANSITION ELEMENTS
VASCULAR DISEASES
ZINC