Effect of varying levels of diet copper upon blood pressure in rats
Conference
·
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:5430466
Two experiments were conducted to evaluate the effects of copper deficiency, adequate diet copper, and excess diet copper upon blood pressure in the rat. In experiment 1, Long-Evans rats whose dams had been fed either a copper restricted diet (0.7 ppm Cu), a copper adequate diet (7.5 ppm Cu), or a commercial ration (7.5 ppm Cu) were maintained on these diets until 100 days of age. Rats in the copper deficient group had lower blood pressure than the chow fed group. In experiment 2, Wistar and Spontaneously Hypertensive Rats (SHR) were divided into two diet copper intake groups at 5 wk of age. One group was fed 18 ppm Cu and the other 100 ppm Cu until the animals were 20 wk of age. Rats fed 100 ppm Cu showed an increase in systolic pressure compared to rats fed 18 ppm Cu. The increase was more pronounced for the Wistar strain and blood pressure in this strain approached the blood pressure of the SHR strain. These changes could not be explained on the basis of urine output or water and feed intake. These studies demonstrated that copper deficiency and excess diet copper intake have dramatic effects upon blood pressure in rats.
- Research Organization:
- Univ. of Wyoming, Laramie
- OSTI ID:
- 5430466
- Report Number(s):
- CONF-8604222-
- Conference Information:
- Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550900 -- Pathology
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BLOOD PRESSURE
CARDIOVASCULAR DISEASES
COPPER
DIET
DISEASES
ELEMENTS
HYPERTENSION
MAMMALS
METALS
NUTRITIONAL DEFICIENCY
PATHOGENESIS
RATS
RODENTS
SYMPTOMS
TRANSITION ELEMENTS
VASCULAR DISEASES
VERTEBRATES
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BLOOD PRESSURE
CARDIOVASCULAR DISEASES
COPPER
DIET
DISEASES
ELEMENTS
HYPERTENSION
MAMMALS
METALS
NUTRITIONAL DEFICIENCY
PATHOGENESIS
RATS
RODENTS
SYMPTOMS
TRANSITION ELEMENTS
VASCULAR DISEASES
VERTEBRATES