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The effect of zinc deficiency on erythrocyte (RBC) deformability as measured by ektacytometer

Conference · · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)
OSTI ID:5214697
;  [1]
  1. Univ. of Saskatchewan, Saskatoon (Canada)
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Experiments were performed to investigate the influence of Zn deficiency on RBC deformability. Weanling, male Wistar rats were fed diets containing < 1 ppm Zn ad libitum for 3 weeks. Controls were fed ad libitum or pair-fed a diet containing 100 ppm Zn. Time zero controls were also included. Blood was sampled from the 4 groups, and RBC deformability was measured at standard shear stress under conditions of increasing osmolality in the ektacytometer. Elongation index was plotted against osmolality. When characteristics of the osmotic spectrum were analyzed by a one-factor ANOVA, maximum cell deformability and Omax were found to be increased between 3 and 6 weeks of age in the rat. The increase in Omax suggests an increase in the water content of the cells. The drop in voluntary food intake which accompanies zinc deficiency significantly decreased EImaz. When the zinc-deficient and pair-fed groups were compared by a paired t-test, the zinc deficient group also showed significantly depressed EImaz. The decrease in EImax is due to either an increase in membrane surface area or a change in membrane shear modulus.

OSTI ID:
5214697
Report Number(s):
CONF-9104107--
Journal Information:
FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Vol. 5:5; ISSN 0892-6638; ISSN FAJOE
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism &amp; Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
ELEMENTS
ERYTHROCYTES
MAMMALS
MATERIALS
METABOLISM
METALS
MORPHOLOGICAL CHANGES
NUTRITIONAL DEFICIENCY
RATS
RODENTS
VERTEBRATES
ZINC