In vivo effects of zinc deficiency on calmodulin concentrations in selected rat tissues
Journal Article
·
· Life Sci.; (United States)
Two groups of male Sprague-Dawley rats, one fed zinc-deficient diet, ad libitum, the other, pair-fed with the same diet, but given supplemental zinc in the drinking water were studied. After ten weeks of diet, rats were exsanguinated and zinc and calmodulin concentration in brain and testes were measured. Mean zinc concentration in testes was significantly decreased in rats fed zinc-deficient diet without supplemental Zn/sup + +/, but mean zinc concentration in brain was not different. Similarly, mean calmodulin concentration in testes was decreased in rats fed zinc-deficient diet without supplemental Zn/sup + +/ whereas mean calmodulin concentration in brain was not different. Distribution studies of zinc and calmodulin showed that both zinc and calmodulin were released more freely into soluble fractions of testes in rats fed zinc-deficient diet without supplemental Zn/sup + +/. These results indicate, for the first time in in vivo studies, that zinc influences the calmodulin content of testes. 26 references, 2 figures, 4 tables.
- Research Organization:
- Center for Molecular Nutrition and Sensory Disorders, Washington, DC (USA)
- OSTI ID:
- 5284462
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 41:24; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
BRAIN
CALMODULIN
CENTRAL NERVOUS SYSTEM
DATA
DIET
ELEMENTS
EXPERIMENTAL DATA
GONADS
IN VIVO
INFORMATION
MALE GENITALS
MAMMALS
METALS
NERVOUS SYSTEM
NUMERICAL DATA
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RATS
RODENTS
SYNTHESIS
TESTES
VERTEBRATES
ZINC
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
BRAIN
CALMODULIN
CENTRAL NERVOUS SYSTEM
DATA
DIET
ELEMENTS
EXPERIMENTAL DATA
GONADS
IN VIVO
INFORMATION
MALE GENITALS
MAMMALS
METALS
NERVOUS SYSTEM
NUMERICAL DATA
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RATS
RODENTS
SYNTHESIS
TESTES
VERTEBRATES
ZINC