Radiation-induced micrencephaly in guinea pigs

Technical Report · Wed Jan 01 04:00:00 EST 1992

DOI:https://doi.org/10.2172/6973401· OSTI ID:6973401

Wagner, L K; Johnston, D A; Felleman, D J

The effect of x rays on brain weight of guinea pig pups at birth was studied for 21-day old embroys exposed in utero to doses of 75 and 100 mGy. When compared to controls and when corrected for body weight, gestation time, litter size, sex, and examiner differences the brains of irradiated pups weighed approximately 46 mg less than those of controls (p<0.001) for the 75-mGy group and about 55 mg less for the 100-mGy group. Brains of females weighed 51 mg less than those of males of the same body weight. Dam weight and caging conditions had no observed effect on brain weight.

• Research Organization: Texas Univ., Houston, TX (United States)
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: FG05-89ER60912
• OSTI ID: 6973401
• Report Number(s): DOE/ER/60912-T1; ON: DE93002866
• Country of Publication: United States
• Language: English

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560162* -- Radionuclide Effects
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CONGENITAL MALFORMATIONS
DOCUMENT TYPES
ELECTROMAGNETIC RADIATION
GUINEA PIGS
IONIZING RADIATIONS
IRRADIATION
MALFORMATIONS
MAMMALS
MATHEMATICS
NERVOUS SYSTEM
ORGANS
PATHOLOGICAL CHANGES
PRENATAL EXPOSURE
PRENATAL IRRADIATION
PROGRESS REPORT
RADIATION EFFECTS
RADIATIONS
REGRESSION ANALYSIS
RODENTS
STATISTICS
VERTEBRATES
WEIGHT
X RADIATION