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Tumor induction in BALB/c mice after fractionated or protracted exposure to fission-spectrum neutrons

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3576150· OSTI ID:6963971

This study has examined the effect of dose rate or fractionation on the carcinogenic effects of fission neutrons with emphasis on the dose range below 50 rad. The induction of lung adenocarcinomas, mammary adenocarcinomas, and ovarian tumors in female BALB/c mice was examined after whole-body neutron irradiation delivered at a high dose rate as a single exposure, or delivered as two equal fractions separated by intervals of 24 hr or 30 days and compared these effects to those after neutron irradiation at low dose rates. The dose responses for ovarian tumorigenesis after the split-dose fractionation regimen were similar to that observed after single high-dose-rate neutron exposure. However, lowering the dose rate reduced the incidence over the dose range of 0-50 rad. For lung and mammary tumors the results were more complex. These data suggest that fractionation and dose-rate effects are different for different tumor types presumably because of the different mechanisms of tumorigenesis that may be involved.

Research Organization:
Oak Ridge National Lab., TN
DOE Contract Number:
W-7405-ENG-26
OSTI ID:
6963971
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 97:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
DATA
DELAYED RADIATION EFFECTS
DISEASES
DOSE RATES
ELEMENTARY PARTICLES
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
FEMALE GENITALS
FERMIONS
FISSION NEUTRONS
FRACTIONATED IRRADIATION
GLANDS
GONADS
HADRONS
INFORMATION
IRRADIATION
LUNGS
MAMMALS
MAMMARY GLANDS
MICE
NEOPLASMS
NEUTRONS
NUCLEONS
NUMERICAL DATA
ORGANS
OVARIES
RADIATION EFFECTS
RADIOINDUCTION
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
WHOLE-BODY IRRADIATION