Neutron carcinogenesis. Dose and dose-rate effects in BALB/c mice

Journal Article · Thu Dec 01 04:00:00 EST 1977 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574612· OSTI ID:6781670

Ullrich, R L; Jernigan, M C; Storer, J B

The influence of dose and dose rate on the tumorigenicity of neutrons was investigated in female BALB/c mice exposed to various doses of neutrons at dose rates of 5 and 25 rad/min or 1 rad/day. The tumors that were most sensitive to induction after neutron exposures included malignant lung adenocarcinomas, mammary adenocarcinomas, and ovarian tumors. For these three tumor types, increased incidences were observed after as little as 5-10 rad of neutrons delivered at a high dose rate. However, after low-dose-rate neutron exposures, different dose-response relationships were observed. Neutron irradiation at low dose rates was less effective than at high dose rates in inducing ovarian tumors at all doses tested. For malignant lung tumors and mammary tumors, on the other hand, the data suggested that the low dose rate was less effective than the high dose rate at low total doses, but more effective at high total doses.

• Research Organization: Oak Ridge National Lab., TN
• OSTI ID: 6781670
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 72:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
DISEASES
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
ELEMENTARY PARTICLES
FEMALE GENITALS
FERMIONS
GLANDS
GONADS
HADRONS
LUNGS
MAMMALS
MAMMARY GLANDS
MICE
NEOPLASMS
NEUTRONS
NUCLEONS
ORGANS
OVARIES
PATHOGENESIS
RADIATION EFFECTS
RADIOINDUCTION
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES