Influence of dose, dose rate, and radiation quality on radiation carcinogenesis and life shortening in RFM and BALB/C mice. [Gamma radiation, fission neutrons]

Conference · Sun Jan 01 04:00:00 EST 1978

OSTI ID:7075670

Ullrich, R L; Storer, J B

The effects produced by /sup 137/Cs gamma rays delivered at a high (45 rads/min) or intermediate (8.2 rads/day) dose rate and the effect of fission neutrons at a high (25 rads/min) and low (1 rad/day) rate in a population of nearly 30,000 RFM and 11,000 BALB/c mice have been studied. Gamma ray doses ranged from 10 to 400 rads with the RFM's and from 50-400 rads with the BALB/c's, while neutron doses ranged from 5 to 200 rads with both strains. The present paper will present an overview of these data and the general findings while subsequent publications will present detailed analyses of each aspect. A variety of neoplasms were sensitive to induction after radiation exposure, including tumors of both reticular tissue origin (leukemia, lymphoma, etc.) and solid tumors. For the RFM, thymic lymphomas were the dominant reticular tissue neoplasm while the majority of solid tumors were either lung adenomas or fit into the broad category of endocrine related tumors, including ovarian, pituitary, harderian, and uterine tumors. The BALB/c was much less sensitive to induction of reticular tissue neoplasms. The tumors that were most sensitive to induction included malignant lung carcinomas, mammary adenocarcinomas and ovarian tumors. In general for both life shortening and tumor induction after gamma ray exposures, when the low to intermediate dose range was sufficiently defined, linearity could be rejected and a dose squared or linear-dose squared relationship adequately fit the data. For neutron exposures, on the other hand, linear relationships were the general finding. The RBE for neutrons varied with tumor type and total dose level. For gamma ray irradiation, the intermediate dose rate resulted in a decreased effectiveness in all cases, while for neutron exposures the dose rate relationships were more complex.

• Research Organization: Oak Ridge National Lab., Tenn. (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 7075670
• Report Number(s): CONF-780306-3
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
DISEASES
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FEMALE GENITALS
FERMIONS
FISSION NEUTRONS
GAMMA RADIATION
GLANDS
GONADS
HADRONS
IONIZING RADIATIONS
LIFE SPAN
LUNGS
MAMMALS
MAMMARY GLANDS
MICE
NEOPLASMS
NEUTRONS
NUCLEONS
ORGANS
OVARIES
PATHOGENESIS
RADIATION EFFECTS
RADIATION QUALITY
RADIATIONS
RADIOINDUCTION
RBE
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES