Tumor induction in BALB/c female mice after fission neutron or. gamma. irradiation

Journal Article · Tue Mar 01 04:00:00 EST 1983 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576029· OSTI ID:5895468

Ullrich, R L

This study was designed to examine the dose-response relationships for tumor induction after neutron irradiation in female BALB/c mice, with emphasis on the response in the dose range 0 to 50 rad. Tumors induced after radiation exposure included ovarian tumors, lung adenocarcinomas, and mammary adenocarcinomas. For comparison the dose responses for induction of these tumors after /sup 137/Cs ..gamma.. irradiation were also examined. As previously described for the female RFM mouse, the data for ovarian tumor induction after neutron and ..gamma.. irradiation were consistent with a threshold model. For lung and mammary tumors the dose-response curve after neutron irradiation appeared to ''bend over'' in the dose range 10 to 20 rad. The factors responsible for this bend-over and their relative contributions to the overall form of the dose-response relationship are not presently known. However, these data strongly indicate that extrapolation from data above 50 rad could result in a significant underestimate of risks. Further, it is clear that current models of neutron carcinogenesis are inadequate, since such a bend-over is not predicted at these low dose levels.

• Research Organization: Oak Ridge National Lab., TN
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5895468
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 93:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMALS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CESIUM 137
CESIUM ISOTOPES
DATA
DELAYED RADIATION EFFECTS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EXPERIMENTAL DATA
FEMALE GENITALS
FEMALES
FERMIONS
FISSION NEUTRONS
GAMMA RADIATION
GLANDS
GONADS
HADRONS
INFORMATION
IONIZING RADIATIONS
ISOTOPES
LUNGS
MAMMALS
MAMMARY GLANDS
MICE
NEOPLASMS
NEUTRONS
NUCLEI
NUCLEONS
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
OVARIES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES