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Distribution and effect of some polychlorinated biphenyls in the hemopoietic tissues. [Monkeys, mice]

Journal Article · · J. Toxicol. Environ. Health; (United States)
OSTI ID:6962633
; ;

Distribution of /sup 14/C-labeled 2,4',5-trichlorobiphenyl 2,2',4,4',5,5'-hexachlorobiphenyl, and 2,2',3,3'4,4',5,6'-octachlorobiphenyl was studied in the hematopoietic tissues of squirrel monkey and mice (C67 Bl) using whole-body autoradiography. An accumulation of radioactivity was seen in the bone marrow of monkey 24 h and 48 h after iv injection of hexachlorobiphenyl and trichlorobiphenyl, respectively. High concentration of radioactivity was also observed in the bone marrow of normal mice injected iv with octachlorobiphenyl. A combination of whole-body autoradiography and spleen-colony assay in supralethally irradiated mice implanted with syngeneic bone-marrow cells indicated the major part of radioactivity to be localized outside the bone-marrow hemic compartment, probably in the fat. No effect of hexachlorobiphenyl but a significant inhibition with octachlorobiphenyl (10/sup -5/ M) and especially trichlorobiphenyl (10/sup -5/ M) was seen on the formation of granulocytic colonies from mouse progenitor cells in vitro.

Research Organization:
Karolinska Hospital, Stockholm, Sweden
OSTI ID:
6962633
Journal Information:
J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 12:4-6; ISSN JTEHD
Country of Publication:
United States
Language:
English

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Related Subjects

560152 -- Radiation Effects on Animals-- Animals
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
AROMATICS
AUTORADIOGRAPHY
BIOASSAY
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BLOOD FORMATION
BODY
BONE MARROW
CARBON 14 COMPOUNDS
CHLORINATED AROMATIC HYDROCARBONS
COLONY FORMATION
DISTRIBUTION
HALOGENATED AROMATIC HYDROCARBONS
HEMATOPOIETIC SYSTEM
IMMUNE REACTIONS
INHIBITION
IRRADIATION
LABELLED COMPOUNDS
MAMMALS
MICE
MONKEYS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PRIMATES
RADIOINDUCTION
RODENTS
SUPRALETHAL IRRADIATION
TISSUE DISTRIBUTION
TISSUES
VERTEBRATES