Myeloid regeneration after whole body irradiation, autologous bone marrow transplantation, and treatment with an anabolic steroid

Journal Article · Wed Jan 01 00:00:00 EST 1975 · J. Med. (Westbury, N.Y.), v. 6, no. 1, pp. 27-32

OSTI ID:4062186

Ambrus, C M; Ambrus, J L

Stumptail monkeys (Macaca speciosa) received lethal whole-body radiation. Autologous bone marrow injection resulted in survival of the majority of the animals. Treatment with Deca-Durabolin, an anabolic steroid, caused more rapid recovery of colony-forming cell numbers in the bone marrow than in control animals. Both the Deca-Durabolin-treated and control groups were given autologous bone marrow transplantation. Anabolic steroid effect on transplanted bone marrow colony-forming cells may explain the increased rate of leukopoietic regeneration in anabolic steroid-treated animals as compared to controls. (auth)

• Research Organization: Roswell Park Memorial Inst., Buffalo
• NSA Number: NSA-33-029711
• OSTI ID: 4062186
• Journal Information: J. Med. (Westbury, N.Y.), v. 6, no. 1, pp. 27-32, Other Information: Orig. Receipt Date: 30-JUN-76
• Country of Publication: United States
• Language: English

Related Subjects

N48520* -Life Sciences-Radiation Effects on Animals- Vertebrates
560152* -Biomedical Sciences
Applied Studies-Radiation Effects-Radiation Effects on Animals-Vertebrates
*LEUKOPOIESIS- BIOLOGICAL REGENERATION
*MONKEYS- BIOLOGICAL RADIATION EFFECTS
*STEROIDS- RADIOSENSITIVITY EFFECTS
BONE MARROW
LETHAL IRRADIATION
TRANSPLANTS
WHOLE-BODY IRRADIATION
X RADIATION