NTP technical report on toxicity studies of O-, M-, and P-nitrotoluenes (CAS Nos. : 88-72-2, 99-08-1, 99-99-0) aministered in dosed feed to f344/n rats and b6c3f1 mice. Toxicity report series

Technical Report · Sat Oct 31 23:00:00 EST 1992

OSTI ID:6943753

Dunnick, J K

Nitrotoluenes are high production volume chemicals used in the synthesis of agricultural and rubber chemicals and in various dyes. Because of differences in the metabolism of the 3 isomers and their capability to bind to DNA, comparative toxicity studies of o-, m-, or p-nitrotoluene were conducted in F344 rats and B6C3F1 mice. Animals were evaluated for histopathology, clinical pathology, and toxicity to the reproductive system. The nitrotoluenes were also studied in several in vitro and in vivo assays for genetic toxicity. The 3 nitrotoluene isomers were toxic to the kidney, spleen and/or reproductive system in rats; o-nitrotoluene also caused lesions in the liver of male rats. The extent of the toxicity was most severe with o-isomer in both rats and mice. o-Nitrotoluene was carcinogenic in male rats in 13-week studies, based on the occurrence of mesothelioma and mesothelial cell hyperplasia in dosed groups.

• Research Organization: National Toxicology Program, Research Triangle Park, NC (United States)
• OSTI ID: 6943753
• Report Number(s): PB-93-150092/XAB; NIH/PUB--93-3346
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGRICULTURAL WASTES
ALKYLATED AROMATICS
ANIMALS
AROMATICS
BODY
CARCINOGENESIS
CHEMISTRY
CONSUMPTION RATES
DIGESTIVE SYSTEM
DNA REPLICATION
DYES
FABRICATION
FOOD
GLANDS
HEMATOLOGY
HYDROCARBONS
IN VITRO
IN VIVO
ISOMERS
LIVER
MAMMALS
MEDICINE
METABOLISM
MICE
NITROGEN COMPOUNDS
NUCLEIC ACID REPLICATION
ORGANIC COMPOUNDS
ORGANIC WASTES
ORGANS
PATHOGENESIS
PATHOLOGY
PRODUCTION
RATS
RESEARCH PROGRAMS
RODENTS
SPLEEN
SYNTHESIS
TOLUENE
TOXICITY
VERTEBRATES
WASTES
WEIGHT