Toxicology studies of cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N rats and B6C3F1 mice (feed studies)

Technical Report · Fri Jan 31 23:00:00 EST 1992

OSTI ID:5263957

Dietz, D D

Cresols are monomethyl derivatives of phenol, and are found as constituents of coal tar, in various industrial solvents and resins, and in some essential oils. In 28-day toxicity studies, F344/N rats and B6C3F1 mice of both sexes were given o-cresol, m0cresol, or m/p-cresol. The cresol isomers exhibited a generally similar pattern of toxicities in rats and mice. Dietary concentrations of 3,000 ppm appeared to be minimal effect levels for increases in liver and kidney weights and 15,000 ppm for deficits in liver function. Histopathologic changes, including bone marrow hypocellularity irritation to the gastrointestinal tract and nasal epithelia, and atrophy of female reproductive organs, occasionally occurred at 10,000 ppm, but were more common at the high dose of 30,000 ppm.

• Research Organization: National Toxicology Program, Research Triangle Park, NC (United States)
• OSTI ID: 5263957
• Report Number(s): PB-92-174242/XAB; NTP-TOX--9
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
AROMATICS
BODY
BONE MARROW
CRESOLS
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
EPITHELIUM
FEMALE GENITALS
GASTROINTESTINAL TRACT
GLANDS
HEMATOPOIETIC SYSTEM
HYDROXY COMPOUNDS
LIVER
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PHENOLS
RATS
RODENTS
TISSUES
TOXICITY
UTERUS
VERTEBRATES