Toxicology and carcinogenesis studies of toluene (CAS No. 108-88-3) in F344/N rats and B6C3F1 mice (inhalation studies). Technical report series

Technical Report · Wed Jan 31 23:00:00 EST 1990

OSTI ID:6481426

Huff, J

Toxicology and carcinogenesis studies were conducted by whole-body inhalation exposure of 50 F344/N rats of each sex and 50 B6C3F1 mice of each sex to 0, 120 (mice only), 600, or 1,200 ppm toluene 6.5 hours per day, 5 days per week, for 103 weeks. Under the conditions of these 2-year inhalation studies, there was no evidence of carcinogenic activity for male or female F344/N rats exposed to toluene at concentrations of 600 or 1,200 ppm. There was no evidence of carcinogenic activity for male or female B6C3F1 mice exposed by inhalation to toluene at concentrations of 120, 600, or 1,200 ppm for 2 years.

• Research Organization: National Toxicology Program, Research Triangle Park, NC (USA)
• OSTI ID: 6481426
• Report Number(s): PB-90-256371/XAB; NTP-TR--371
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATED AROMATICS
ANIMALS
AROMATICS
CARCINOGEN SCREENING
HYDROCARBONS
INHALATION
INTAKE
MAMMALS
METABOLISM
MICE
ORGANIC COMPOUNDS
RATS
RODENTS
SCREENING
TOLUENE
VERTEBRATES