NTP technical report on the toxicology and carcinogenesis studies of ozone (Cas No. 10028-15-6) and ozone/NNK (Cas No. 10028-15-6/64091-91-4) in F344/N rats and B6C3F1 mice (inhalation studies). Technical report series
Toxicology and carcinogenicity studies were conducted by administering ozone by inhalation to groups of 50 male and female F344/N rats at doses 0, 0.12, 0.5, or 1.0 ppm for 6 hours per day, 5 days per week, for 105 weeks and 50 male and 50 female F344/N rats and B6C3F1 mice were exposed to 0, 0.5, or 1.0 ppm ozone for up to 125 weeks, and groups of male F344/N rats were exposed to 0.5 ppm ozone along with a lung carcinogen, NNK, to determine if ozone had any promoting or cocarcinogenic effects. Under the conditions of these 2-year and lifetime inhalation studies, there was no evidence of carcinogenic activity of ozone in male or female F344/N rats exposed to 0.12, 0.5, or 1.0 ppm. There was equivocal evidence of carcinogenic activity of ozone in male B6C3F1 mice based on increased incidences of alveolar/bronchiolar adenoma or carcinoma. There was some evidence of carcinogenic activity of ozone in female B6C3F1 mice based on increased incidences of alveolar/bronchiolar adenoma or carcinoma.
- Research Organization:
- National Toxicology Program, Research Triangle Park, NC (United States)
- OSTI ID:
- 80619
- Report Number(s):
- PB--95-226999/XAB; NIH/PUB--95-3371
- Country of Publication:
- United States
- Language:
- English
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