Carcinogenesis studies of trichloroethylene (without epichlorohydrin) (CAS No. 79-01-6) in F344/N rats and B6C3F1 mice (gavage studies). Technical report series (Final)

Technical Report · Tue May 01 00:00:00 EDT 1990

OSTI ID:6358511

Carcinogenesis studies of epichlorohydrin-free trichloroethylene were conducted by administering the test chemical in corn oil by gavage to groups of 50 male and 50 female F344/N rats and 50 B6C3F1 mice of each sex for 103 weeks. Dose levels were 500 and 1,000 mg/kg for rats and 1,000 mg/kg for mice. Under the conditions of these studies, epichlorohydrin-free trichloroethylene caused renal tubular-cell neoplasms in male F344/N rats, produced toxic nephrosis in both sexes, and shortened the survival time of males. The experiment in male F344/N rats was considered to be inadequate to evaluate the presence or absence of a carcinogenic response to trichloroethylene. For female F344/N rats receiving trichloroethylene containing no epichlorohydrin, there was no evidence of carcinogenicity. Trichloroethylene (without epichlorohydrin) was carcinogenic for B6C3F1 mice, causing increased incidences of hepatocellular carcinomas in males and females and hepatocellular adenomas in females.

• Research Organization: National Toxicology Program, Research Triangle Park, NC (USA)
• OSTI ID: 6358511
• Report Number(s): PB-91-111815/XAB; NTP-TR--243
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOMAS
ANIMALS
CARCINOGENESIS
CARCINOMAS
CHLORINATED ALIPHATIC HYDROCARBONS
DISEASES
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
HALOGENATED ALIPHATIC HYDROCARBONS
MAMMALS
MICE
NEOPLASMS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PATHOGENESIS
PROGRESS REPORT
RATS
RODENTS
SEX DEPENDENCE
SURVIVAL CURVES
VERTEBRATES