Toxicology and carcinogenesis studies of tribromomethane (bromoform) (CAS No. 75-25-2) in F344/N rats and B6C3f1 mice (gavage studies). Technical report series

Technical Report · Mon May 01 00:00:00 EDT 1989

OSTI ID:5257129

Melnick, R L

Toxicology and carcinogenesis studies were conducted by administering doses of 0, 100, or 200 mg/kg tribromomethane in corn oil by gavage, 5 days per week for a period of 103 weeks, to groups of 50 rats of each sex and 50 female mice. Groups of 50 male mice were administered 0, 50, or 100 mg/kg tribromomethane on the same schedule. Under the conditions of these 2-year gavage studies, there was some evidence of carcinogenic activity of tribromomethane for male F344/N rats and clear evidence of carcinogenic activity for female F344/N rats, based on increased incidence of uncommon neoplasms of the large intestine. Reduced survival for male rats given 200 mg/kg tribromomethane lowered the sensitivity of the group to detect a carcinogenic response. Chemically related noneoplastic lesions included fatty change and active chronic inflammation of the liver in male and female rats, minimal necrosis of the liver in male rats, and mixed cell foci of the liver in female rats. There was no evidence of carcinogenic activity for male B6C3F1 mice given 50 or 100 mg/kg tribromomethane or for female B6C3F1 mice given 100 or 200 mg/kg; male mice might have been able to tolerate a higher dose. Survival of the female mice was reduced, partly due to a utero-ovarian infection.

• Research Organization: National Toxicology Program, Research Triangle Park, NC (USA)
• OSTI ID: 5257129
• Report Number(s): PB-90-110149/XAB; NTP-TR-350
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BROMOFORM
CARCINOGENESIS
BIOASSAY
ENVIRONMENTAL EXPOSURE
LABORATORY ANIMALS
MICE
NEOPLASMS
PROGRESS REPORT
RATS
TOXICITY
ANIMALS
BROMINATED ALIPHATIC HYDROCARBONS
DISEASES
DOCUMENT TYPES
HALOGENATED ALIPHATIC HYDROCARBONS
MAMMALS
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PATHOGENESIS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology