Multiple-site carcinogenicity of benzene in fischer 344 rats and B6C3F1 mice

Technical Report · Sat Dec 31 23:00:00 EST 1988

OSTI ID:6983039

Huff, J E; Haseman, J K; DeMarini, D M; Eustis, S; Maronpot, R R

Two-year toxicology and carcinogenesis studies of benzene were conducted in groups of 50 F344/N rats and 50 B6C3F1 mice of each sex and for each of three exposure doses and vehicle controls. These studies were conducted because of large production volume and widespread human exposure to benzene, because of the epidemiologic association with leukemia, and because previous studies were considered inadequate for determining carcinogenicity. Doses of 0, 50, 100 or 200 mg/kg body weight benzene in corn oil (5 ml/kg) were administered by gavage to male rats, 5 days per week for 103 weeks. Doses of 0, 25, 50, or 100 mg/kg benzene in corn oil were administered by gavage to female rats and to male and female mice for 103 weeks. At week 92 for rats and week 91 for mice, survival was greater than 60% in all groups; most of the animals that died before week 103 had neoplasia. Benzene-associated nonneoplastic or neoplastic effects on the hematopoietic system, Zymbal gland, forestomach, and adrenal gland were found for rats and mice.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
• OSTI ID: 6983039
• Report Number(s): PB-90-146069/XAB; EPA--600/J-89/224
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZENE
CARCINOGEN SCREENING
DISEASES
DOSE-RESPONSE RELATIONSHIPS
HEMIC DISEASES
HYDROCARBONS
IMMUNE SYSTEM DISEASES
LEUKEMIA
MAMMALS
METABOLIC ACTIVATION
MICE
NEOPLASMS
ORGANIC COMPOUNDS
RATS
RODENTS
SCREENING
SURVIVAL TIME
TOXICITY
VERTEBRATES