Toxicology and carcinogenesis studies of benzyl alcohol (CAS No. 100-51-6) in F344/N rats and B6C3f1 mice (gavage studies). Technical report series

Technical Report · Thu Jun 01 04:00:00 EDT 1989

OSTI ID:5223416

Dieter, M P

Two-year toxicology and carcinogenesis studies of benzyl alcohol were conducted by administering the chemical in corn oil by gavage to groups of 50 rats of each sex at doses of 0, 200, or 400 mg/kg. Groups of 50 mice of each sex were administered 0, 100, or 200 mg/kg according to the same schedule. Under the conditions of these 2-year gavage studies, there was no evidence of carcinogenic activity of benzyl alcohol for male or female F344/N rats dosed with 200 or 400 mg/kg. Survival in both dose groups of female rats was 50% that of vehicle controls, primarily due to an increased number of gavage-related deaths. There was no evidence of carcinogenic activity of benzyl alcohol for male or female B6C3F1 mice dosed with 100 or 200 mg/kg for 2 years.

• Research Organization: National Toxicology Program, Research Triangle Park, NC (USA)
• OSTI ID: 5223416
• Report Number(s): PB-90-110206/XAB; NTP-TR--343
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
AROMATICS
BENZYL ALCOHOL
BIOASSAY
CARCINOGENESIS
DOCUMENT TYPES
ENVIRONMENTAL EXPOSURE
HYDROXY COMPOUNDS
LABORATORY ANIMALS
MAMMALS
MICE
ORGANIC COMPOUNDS
PATHOGENESIS
PROGRESS REPORT
RATS
RODENTS
TOXICITY
VERTEBRATES