Toxicology and carcinogenesis studies of hexachloroethane (CAS No. 67-72-1) in F344/N rats (gavage studies). Technical report

Technical Report · Tue Aug 01 04:00:00 EDT 1989

OSTI ID:6905577

Eastin, W C

Toxicology and carcinogenesis studies were conducted by administering doses of 0, 10, or 20 mg/kg hexachloroethane in corn oil by gavage 5 days per week for 103 weeks to groups of 50 male rats. Groups of 50 female rats were administered 0, 80, or 160 mg/kg on the same schedule. Under the conditions of these 2-year gavage studies, there was clear evidence of carcinogenic activity of hexachloroethane for male F344/N rats, based on the increased incidences of renal neoplasms. The marginally increased incidences of pheochromocytomas of the adrenal gland may have been related to hexachloroethane administration to male rats. There was no evidence of carcinogenic activity of hexachloroethane for female F344/N rats administered 80 or 160 mg/kg by gavage for 103 weeks.

• Research Organization: National Toxicology Program, Research Triangle Park, NC (USA)
• OSTI ID: 6905577
• Report Number(s): PB-90-170895/XAB; NTP-TR--361
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
ANIMALS
BIOASSAY
BODY
CARCINOGENESIS
CHLORINATED ALIPHATIC HYDROCARBONS
DISEASES
DOCUMENT TYPES
ENDOCRINE GLANDS
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
KIDNEYS
MAMMALS
NEOPLASMS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PATHOGENESIS
PROGRESS REPORT
RATS
RODENTS
SEX DEPENDENCE
VERTEBRATES