NTP technical report on the toxicology and carcinogenesis studies of benzethonium chloride (Cas No. 121-54-0) in F344/N rats and B6C3F1 mice (dermal studies). Technical report series
Toxicology and carcinogenicity studies were conducted by dermal administration of benzethonium chloride to groups of 60 F344/N rats and 60 B6C3F1 mice of each sex at doses of 0, 0.15, 0.5, or 1.5 mg/kg body weight. Benzethonium chloride was administered to rats in ethanol 5 days per week and doses were adjusted weekly according to the average body weights of the groups. Under the conditions of these 2 year dermal studies, there was no evidence of carcinogenic activity of benzethonium chloride in male or female F344/N rats or in male or female B6C3F1 mice. Exposure of rats and mice to benzethonium chloride by dermal application in ethanol for 2 years resulted in epithelial hyperplasia in male and female rats and mice and sebaceous gland hyperplasia and ulcers in female rats at the site of application.
- Research Organization:
- National Toxicology Program, Research Triangle Park, NC (United States)
- OSTI ID:
- 239055
- Report Number(s):
- PB--96-162300/XAB; NTP-TR--438
- Country of Publication:
- United States
- Language:
- English
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