NTP technical report on toxicity studies of ethylene glycol ethers 2-methoxyethanol, 2-ethoxyethanol, 2-butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) administered by drinking water to F344/N rats and B6C3F1 mice. Toxicity report series

Technical Report · Thu Jul 01 00:00:00 EDT 1993

OSTI ID:5475116

Dieter, M P

Glycol alkyl ethers represent a class of high-production-volume chemicals with widespread industrial applications as solvents and chemical intermediates. Comparative toxicity studies with three glycol ethers, 2-methoxyethanol, 2-ethoxyethanol, and 2-butoxyethanol, were conducted in F344/N rats and B6C3F1 mice in both 2-week and 13-week drinking water studies. Toxicologic endpoints evaluated in animals included histopathology, hematology, clinical chemistry, urinalysis, and reproductive system parameters. Genetic toxicity was also evaluated for each glycol ether in several in vitro and in vivo assays.

• Research Organization: National Toxicology Program, Research Triangle Park, NC (United States)
• OSTI ID: 5475116
• Report Number(s): PB-94-118106/XAB; NIH/PUB--93-3349
• Country of Publication: United States
• Language: English

Related Subjects

550400 -- Genetics
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ALKENES
BIOLOGICAL EFFECTS
ETHYLENE
GENETIC EFFECTS
GLYCOLS
HYDROCARBONS
HYDROXY COMPOUNDS
ORGANIC COMPOUNDS
TOXICITY