NTP technical report on toxicity studies of diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/n rats and B6C3F1 mice. Toxicity report series
Diethanolamine is a high-production chemical used in cosmetics, in cutting fluids, as a dispersing agent for agricultural chemicals, and as an absorbent for acidic gases. Toxicology studies of diethanolamine were conducted in F344/N rats and B6C3F1 mice of both sexes for 2 weeks (5/sex/species/dose) and 13 weeks (10/sex/species/dose) to characterize and compare the effects of oral and dermal exposure. In addition to histopathology, evaluations included clinical pathology, urinalyses, and sperm morphology or vaginal cytology. In vitro genetic toxicity studies included assessments of mutagenicity in Salmonella typhimurium and mouse lymphoma L5178Y cells, analysis of chromosomal aberrations and sister chromatid exchange in Chinese hamster ovary cells, and determination of micronuclei formed in mice during the 13 week dermal exposure study. In the 13-week drinking water study in mice, nephropathy and tubular necrosis were observed in males, and degeneration of cardiac myocytes, and hepatocellular necrosis were seen in males and females. Cytologic alteration in the submandibular salivary gland was noted in male and female mice. Hepatocyte cytologic alteration also was noted in all dosed groups of mice.
- Research Organization:
- National Toxicology Program, Research Triangle Park, NC (United States)
- OSTI ID:
- 6713508
- Report Number(s):
- PB-93-133999/XAB; NIH/PUB--92-3343
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGRICULTURAL WASTES
ANIMALS
BACTERIA
BIOLOGY
CARCINOGENS
CHEMICAL ANALYSIS
CHROMOSOMAL ABERRATIONS
COMMERCIAL SECTOR
CUTTING FLUIDS
CYTOLOGY
DRINKING WATER
FEMALES
FLUIDS
GENETICS
HYDROGEN COMPOUNDS
IN VITRO
LABORATORY ANIMALS
MALES
MAMMALS
MICE
MICROORGANISMS
MORPHOLOGY
MORTALITY
MUTATIONS
NECROSIS
OCCUPATIONAL SAFETY
ORGANIC WASTES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PATHOLOGY
PUBLIC HEALTH
RATS
REPRODUCTION
RESEARCH PROGRAMS
RODENTS
SAFETY
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SEX DEPENDENCE
TOXICITY
VERTEBRATES
WASTES
WATER