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Title: Use of 2-deoxy-D(1-/sup 11/C)glucose for the determination of local cerebral glucose metabolism in humans: variation within and between subjects

Abstract

The deoxyglucose technique for the measurement of local cerebral glucose metabolism (LCMRgl) has been widely applied in animals utilizing /sup 14/C-deoxyglucose and in humans employing /sup 18/F-fluorodeoxyglucose. Repeat studies in humans over a relatively brief period of time have not been possible because of the 110-min half-life of /sup 18/F. With the synthesis of /sup 11/C-deoxyglucose it has now become possible to utilize this short-lived (20 min) tracer for the measurement of LCMRgl and to determine its variability within subjects over a 2-h period. The kinetic rate constants for /sup 11/C-deoxyglucose were determined for gray and white matter and found to be very similar to those for /sup 18/F-fluorodeoxyglucose, suggesting that these two analogues of glucose have similar affinities for the facilitated transport system and are similar substrates for hexokinase in the brain. The coefficient of variation of repeated measurements of LCMRgl in a series of six normal subjects was 5.5% to 8.7% for various gray matter structures and 9.7% and 14.0% for white matter structures. The pattern of cerebral metabolic rates is relatively constant in a given individual when the conditions of the study are unchanged. The ability to make repeat measurements in the same subject reduces the variancemore » due to between-subject differences, allowing smaller changes in LCMRgl to be detected with confidence.« less

Authors:
; ; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Cerebrovascular Research Center of the Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia
OSTI Identifier:
6943408
Resource Type:
Journal Article
Journal Name:
J. Cereb. Blood Flow Metab.; (United States)
Additional Journal Information:
Journal Volume: 2:3
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; CARBON 11; DIAGNOSTIC USES; CARBON 14 COMPOUNDS; CEREBRUM; SCINTISCANNING; FLUORINE 18; GLUCOSE; METABOLISM; BLOOD FLOW; GENETIC VARIABILITY; PATIENTS; RADIATION DOSES; ALDEHYDES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BIOLOGICAL VARIABILITY; BODY; BRAIN; CARBOHYDRATES; CARBON ISOTOPES; CENTRAL NERVOUS SYSTEM; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DOSES; EVEN-ODD NUCLEI; FLUORINE ISOTOPES; HEXOSES; HOURS LIVING RADIOISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; MONOSACCHARIDES; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SACCHARIDES; USES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550501 - Metabolism- Tracer Techniques

Citation Formats

Reivich, M, Alavi, A, Wolf, A, Greenberg, J H, Fowler, J, Christman, D, MacGregor, R, Jones, S C, London, J, Shiue, C, and Yonekura, Y. Use of 2-deoxy-D(1-/sup 11/C)glucose for the determination of local cerebral glucose metabolism in humans: variation within and between subjects. United States: N. p., 1982. Web. doi:10.1038/jcbfm.1982.32.
Reivich, M, Alavi, A, Wolf, A, Greenberg, J H, Fowler, J, Christman, D, MacGregor, R, Jones, S C, London, J, Shiue, C, & Yonekura, Y. Use of 2-deoxy-D(1-/sup 11/C)glucose for the determination of local cerebral glucose metabolism in humans: variation within and between subjects. United States. https://doi.org/10.1038/jcbfm.1982.32
Reivich, M, Alavi, A, Wolf, A, Greenberg, J H, Fowler, J, Christman, D, MacGregor, R, Jones, S C, London, J, Shiue, C, and Yonekura, Y. 1982. "Use of 2-deoxy-D(1-/sup 11/C)glucose for the determination of local cerebral glucose metabolism in humans: variation within and between subjects". United States. https://doi.org/10.1038/jcbfm.1982.32.
@article{osti_6943408,
title = {Use of 2-deoxy-D(1-/sup 11/C)glucose for the determination of local cerebral glucose metabolism in humans: variation within and between subjects},
author = {Reivich, M and Alavi, A and Wolf, A and Greenberg, J H and Fowler, J and Christman, D and MacGregor, R and Jones, S C and London, J and Shiue, C and Yonekura, Y},
abstractNote = {The deoxyglucose technique for the measurement of local cerebral glucose metabolism (LCMRgl) has been widely applied in animals utilizing /sup 14/C-deoxyglucose and in humans employing /sup 18/F-fluorodeoxyglucose. Repeat studies in humans over a relatively brief period of time have not been possible because of the 110-min half-life of /sup 18/F. With the synthesis of /sup 11/C-deoxyglucose it has now become possible to utilize this short-lived (20 min) tracer for the measurement of LCMRgl and to determine its variability within subjects over a 2-h period. The kinetic rate constants for /sup 11/C-deoxyglucose were determined for gray and white matter and found to be very similar to those for /sup 18/F-fluorodeoxyglucose, suggesting that these two analogues of glucose have similar affinities for the facilitated transport system and are similar substrates for hexokinase in the brain. The coefficient of variation of repeated measurements of LCMRgl in a series of six normal subjects was 5.5% to 8.7% for various gray matter structures and 9.7% and 14.0% for white matter structures. The pattern of cerebral metabolic rates is relatively constant in a given individual when the conditions of the study are unchanged. The ability to make repeat measurements in the same subject reduces the variance due to between-subject differences, allowing smaller changes in LCMRgl to be detected with confidence.},
doi = {10.1038/jcbfm.1982.32},
url = {https://www.osti.gov/biblio/6943408}, journal = {J. Cereb. Blood Flow Metab.; (United States)},
number = ,
volume = 2:3,
place = {United States},
year = {Wed Sep 01 00:00:00 EDT 1982},
month = {Wed Sep 01 00:00:00 EDT 1982}
}