Use of 2-deoxy-D(1-/sup 11/C)glucose for the determination of local cerebral glucose metabolism in humans: variation within and between subjects

Journal Article · Wed Sep 01 04:00:00 EDT 1982 · J. Cereb. Blood Flow Metab.; (United States)

DOI:https://doi.org/10.1038/jcbfm.1982.32· OSTI ID:6943408

Reivich, M; Alavi, A; Wolf, A; Greenberg, J H; Fowler, J; Christman, D; MacGregor, R; Jones, S C; London, J; Shiue, C; Yonekura, Y

The deoxyglucose technique for the measurement of local cerebral glucose metabolism (LCMRgl) has been widely applied in animals utilizing /sup 14/C-deoxyglucose and in humans employing /sup 18/F-fluorodeoxyglucose. Repeat studies in humans over a relatively brief period of time have not been possible because of the 110-min half-life of /sup 18/F. With the synthesis of /sup 11/C-deoxyglucose it has now become possible to utilize this short-lived (20 min) tracer for the measurement of LCMRgl and to determine its variability within subjects over a 2-h period. The kinetic rate constants for /sup 11/C-deoxyglucose were determined for gray and white matter and found to be very similar to those for /sup 18/F-fluorodeoxyglucose, suggesting that these two analogues of glucose have similar affinities for the facilitated transport system and are similar substrates for hexokinase in the brain. The coefficient of variation of repeated measurements of LCMRgl in a series of six normal subjects was 5.5% to 8.7% for various gray matter structures and 9.7% and 14.0% for white matter structures. The pattern of cerebral metabolic rates is relatively constant in a given individual when the conditions of the study are unchanged. The ability to make repeat measurements in the same subject reduces the variance due to between-subject differences, allowing smaller changes in LCMRgl to be detected with confidence.

• Research Organization: Cerebrovascular Research Center of the Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia
• OSTI ID: 6943408
• Journal Information: J. Cereb. Blood Flow Metab.; (United States), Journal Name: J. Cereb. Blood Flow Metab.; (United States) Vol. 2:3; ISSN JCBMD
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL VARIABILITY
BLOOD FLOW
BODY
BRAIN
CARBOHYDRATES
CARBON 11
CARBON 14 COMPOUNDS
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
CEREBRUM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DOSES
EVEN-ODD NUCLEI
FLUORINE 18
FLUORINE ISOTOPES
GENETIC VARIABILITY
GLUCOSE
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
METABOLISM
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
RADIATION DOSES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SACCHARIDES
SCINTISCANNING
USES