Local cerebral glucose utilization in the beagle puppy model of intraventricular hemorrhage

Journal Article · Wed Sep 01 04:00:00 EDT 1982 · J. Neurosurg.; (United States)

DOI:https://doi.org/10.3171/jns.1982.57.3.0384· OSTI ID:6706316

Ment, L R; Stewart, W B; Duncan, C C

Local cerebral glucose utilization has been measured by means of carbon-14(/sup 14/C)-autoradiography with 2-deoxyglucose in the newborn beagle puppy model of intraventricular hemorrhage. Our studies demonstrate gray matter/white matter differentiation of uptake of /sup 14/C-2-deoxyglucose in the control pups, as would be expected from adult animal studies. However, there is a marked homogeneity of /sup 14/C-2-deoxyglucose uptake in all brain regions in the puppies with intraventricular hemorrhage, possibly indicating a loss of the known coupling between cerebral blood flow and metabolism in this neuropathological condition.

• Research Organization: Department of Pediatrics, Neurology, Neurosurgery, and Gross Anatomy, Yale University School of Medicine, New Haven, Connecticut
• OSTI ID: 6706316
• Journal Information: J. Neurosurg.; (United States), Journal Name: J. Neurosurg.; (United States) Vol. 57:3; ISSN JONSA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMALS
AUTORADIOGRAPHY
BEAGLES
BLOOD FLOW
BODY
BRAIN
CARBOHYDRATES
CARBON 14 COMPOUNDS
CENTRAL NERVOUS SYSTEM
CEREBRUM
DOGS
GLUCOSE
HEMORRHAGE
HEXOSES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATHOLOGY
SACCHARIDES
SYMPTOMS
VERTEBRATES