Beagle puppy model of intraventricular hemorrhage: effect of indomethacin on cerebral blood flow

Journal Article · Wed Jun 01 04:00:00 EDT 1983 · J. Neurosurg.; (United States)

DOI:https://doi.org/10.3171/jns.1983.58.6.0857· OSTI ID:6097009

Ment, L R; Stewart, W B; Duncan, C C; Scott, D T; Lambrecht, R

The newborn beagle puppy has been demonstrated to provide a good model for neonatal intraventricular hemorrhage (IVH). A study was designed to determine if indomethacin can prevent IVH and if indomethacin would produce changes in cerebral blood flow (CBF). Newborn beagle puppies were randomized by computer into two groups: one was pretreated with indomethacin, a known inhibitor of prostaglandin synthetase, and the other was saline. The dogs in both groups were then assigned either to undergo hemorrhagic hypotension/volume reexpansion insult or to receive no insult. Twenty percent of all pups receiving indomethacin and undergoing the insult experienced IVH, compared to 71% of the pups undergoing insult that had been pretreated with saline. Significant alterations in the blood pressure responses to the hemorrhagic hypotension/volume reexpansion insult were noted in the former group compared to the saline-pretreated pups subjected to insult. Finally, employing carbon-14 autoradiography for the determination of CBF, it was demonstrated that indomethacin decreases resting CBF of the newborn beagle pups and, in indomethacin-pretreated animals subjected to insult, prevents the increases in CBF seen in the saline-pretreated traumatized pups. 62 references, 1 figure, 3 tables.

• Research Organization: Yale Univ. School of Medicine, New Haven, CT
• OSTI ID: 6097009
• Journal Information: J. Neurosurg.; (United States), Journal Name: J. Neurosurg.; (United States) Vol. 58; ISSN JONSA
• Country of Publication: United States
• Language: English

Related Subjects

551001 -- Physiological Systems-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETIC ACID
ALKALI METAL COMPOUNDS
ANIMALS
AROMATICS
AUTORADIOGRAPHY
AZAARENES
AZOLES
BIOLOGICAL EFFECTS
BLOOD FLOW
BODY
BRAIN
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CEREBRUM
CHLORIDES
CHLORINE COMPOUNDS
DATA
DOGS
ENZYME INHIBITORS
EXPERIMENTAL DATA
HALIDES
HALOGEN COMPOUNDS
HEMORRHAGE
HETEROCYCLIC COMPOUNDS
INDOLES
INFORMATION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATHEMATICAL MODELS
MONOCARBOXYLIC ACIDS
NEONATES
NERVOUS SYSTEM
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PYRROLES
SODIUM CHLORIDES
SODIUM COMPOUNDS
SYMPTOMS
TRACER TECHNIQUES
VERTEBRATES