Glucose metabolic rate kinetic model parameter determination in humans: the lumped constants and rate constants for (/sup 18/F)fluorodeoxyglucose and (/sup 11/C)deoxyglucose

Journal Article · Sat Jun 01 04:00:00 EDT 1985 · J. Cereb. Blood Flow Metab.; (United States)

DOI:https://doi.org/10.1038/jcbfm.1985.24· OSTI ID:5022258

Reivich, M; Alavi, A; Wolf, A; Fowler, J; Russell, J; Arnett, C; MacGregor, R R; Shiue, C Y; Atkins, H; Anand, A

The rate constants and lumped constants (LCs) for (/sup 18/F)fluorodeoxyglucose ((/sup 18/F)FDG) and (/sup 11/C)deoxyglucose ((/sup 11/C)DG) were determined in humans for the glucose metabolic rate kinetic model used to measure local cerebral glucose consumption. The mean values of the LCs for (/sup 18/F)FDG and (/sup 11/C)DG are 0.52 and 0.56, respectively. The mean values of the rate constants k*1, k*2, k*3, and k*4 for (/sup 18/F)FDG for gray matter are 0.095, 0.125, 0.069, and 0.0055, respectively. The corresponding values for white matter are 0.065, 0.126, 0.066, and 0.0054, respectively. Using these values and previously published values for the rate constants for (/sup 11/C)DG, the average whole-brain metabolic rates for glucose in normal subjects measured with (/sup 18/F)FDG and (/sup 11/C)DG are 5.66 and 4.99 mg/100 g/min, respectively. These values are not significantly different and agree well with reported values in the literature determined by means of the Kety-Schmidt technique.

• Research Organization: Univ. of Pennsylvania, Philadelphia
• OSTI ID: 5022258
• Journal Information: J. Cereb. Blood Flow Metab.; (United States), Journal Name: J. Cereb. Blood Flow Metab.; (United States) Vol. 2; ISSN JCBMD
• Country of Publication: United States
• Language: English

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