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Determination of the lumped constant and the kinetic constants for deoxyglucose and fluorodeoxyglucose in man

Conference ·
OSTI ID:5179330
; ; ; ; ; ; ; ; ;
If both the time course of the arterial plasma radionuclide concentration and the brain tissue radionuclide concentrations are known, it is possible to calculate the kinetic constants (k/sub 1/*, k/sub 2/*, k/sub 3/*, k/sub 4/*) of the glucose analogue. In a series of male subjects, arterial blood samples were obtained at frequent intervals immediately following the bolus administration of /sup 18/F-FDG and then at less frequent intervals for up to 5 hours after the radionuclide administration. The tissue time course was obtained by making positron emission tomographic scans every three minutes for 30 minutes and then at less frequent intervals for 5 hours. These images were used to construct the time course of /sup 18/F activity in gray and white matter structures. Using these values for the lumped constants and the kinetic constants, the values obtained for the global metabolic rate for glucose in two series of young male subjects were 4.99 +- 0.23 and 5.55 +- 0.37 mg/100 g/min when /sup 11/C-DG and /sup 18/F-FDG were used as tracers respectively.
Research Organization:
Pennsylvania Univ., Philadelphia (USA). Cerebrovascular Research Center; Brookhaven National Lab., Upton, NY (USA)
DOE Contract Number:
AC02-76CH00016
OSTI ID:
5179330
Report Number(s):
BNL-36937; CONF-8506187-2; ON: DE86000317
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANIMALS
ANTIMETABOLITES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
FLUORINE 18
FLUORINE ISOTOPES
FLUORODEOXYGLUCOSE
GLUCOSE
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MAN
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
RADIOISOTOPES
RADIOPHARMACEUTICALS
REACTION KINETICS
SACCHARIDES
TOMOGRAPHY
VERTEBRATES