Biochemical diagnosis of occupational exposure to lead toxicity
- Sri Venkateswara Univ., Andhra Pradesh (India)
Lead has been shown to interfere with the biosynthesis of heme in a number of in vitro systems and in experimental animals as well as in human beings. Several steps of the heme biosynthetic chain are subject to the toxic effects of lead. ALA- dehydratase and Ferrochelatase, in particular, are two enzymes which are strongly inhibited by lead, leading to decreased heme synthesis, a constituent of hemoglobin. The inhibition of ALA dehydratase in the red blood cells by lead is generally recognized as the most sensitive index of the individuals exposure to this environmental chemical. Earlier reports show that the determination of blood lead content (Pb-B), zinc protoporphyrin levels and erythrocyte Aminolevulinic acid dehydratase (ALA.D) are widely used as biological indicators for lead toxicity. Hence, the aim of the present study was to screen for occupational exposure to lead in the workers of three different occupations and correlate their blood lead levels with erythrocyte ALA.D and total blood porphyrin content as biochemical indicators of lead exposure.
- OSTI ID:
- 6943004
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology; (USA), Journal Name: Bulletin of Environmental Contamination and Toxicology; (USA) Vol. 44:2; ISSN 0007-4861; ISSN BECTA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
AMINOLEVULINIC ACID
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL PATHWAYS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
ENZYME ACTIVITY
ENZYMES
ERYTHROCYTES
GLOBINS
HEME
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
LEAD COMPOUNDS
MALES
MAMMALS
MAN
MATERIALS
MEN
OCCUPATIONAL EXPOSURE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
PIGMENTS
PORPHYRINS
PRIMATES
PROTEINS
SYNTHESIS
TOXICITY
VERTEBRATES