Subclinical effects of chronic increased lead absorption--a prospective study. Part IV. Evaluation of heme synthesis effects

Journal Article · Mon Feb 01 04:00:00 EST 1982 · J. Occup. Med.; (United States)

OSTI ID:5510062

Valentine, J L; Baloh, R W; Browdy, B L; Gonick, H C; Brown, C P; Spivey, G H; Culver, B D

The effects of lead exposure on heme synthesis in workers with subclinical responses and in controls were evaluated. delta-Aminolevulinic acid dehydratase (ALA-d) correlated significantly with blood lead levels in the control group but not with those in the exposed group. Free erythrocyte protoporphyrin correlated significantly with blood lead levels in the exposed group but not with those in the controls and was found to be a good indicator of blood lead history among exposed persons. Hemoglobin values determined at initial employment were not statistically different from those determined during the baseline test for a group of 12 workers with a maximum blood lead level of 86 micrograms/100 ml during their exposure history. The effect such heme inhibition may have on other body functions is uncertain.

• Research Organization: School of Public Health, UCLA
• OSTI ID: 5510062
• Journal Information: J. Occup. Med.; (United States), Journal Name: J. Occup. Med.; (United States) Vol. 24:2; ISSN JOCMA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
BIOLOGICAL EFFECTS
BIOSYNTHESIS
CARBOXYLIC ACIDS
ELEMENTS
ENZYMES
GLOBIN
HEME
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INHIBITION
KETO ACIDS
LEAD
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
PERSONNEL
PIGMENTS
PORPHYRINS
PROTEINS
PROTOPORPHYRINS
SYNTHESIS