Subclinical effects of chronic increased lead absorption--a prospective study. Part IV. Evaluation of heme synthesis effects
The effects of lead exposure on heme synthesis in workers with subclinical responses and in controls were evaluated. delta-Aminolevulinic acid dehydratase (ALA-d) correlated significantly with blood lead levels in the control group but not with those in the exposed group. Free erythrocyte protoporphyrin correlated significantly with blood lead levels in the exposed group but not with those in the controls and was found to be a good indicator of blood lead history among exposed persons. Hemoglobin values determined at initial employment were not statistically different from those determined during the baseline test for a group of 12 workers with a maximum blood lead level of 85 ..mu..g/100 ml during their exposure history. The effect such heme inhibition may have on other body functions is uncertain.
- OSTI ID:
- 5656887
- Journal Information:
- J. Occup. Med.; (United States), Journal Name: J. Occup. Med.; (United States) Vol. 24:2; ISSN JOCMA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION SPECTROSCOPY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BODY FLUIDS
CARBOXYLIC ACIDS
ELEMENTS
ENZYME ACTIVITY
GLOBIN
HAZARDS
HEALTH HAZARDS
HEME
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
LEAD
MATERIALS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATIENTS
PERSONNEL
PIGMENTS
PORPHYRINS
PROTEINS
PROTOPORPHYRINS
SMELTERS
SPECTROSCOPY
SYNTHESIS