Comparative study regarding the association of alpha-2U globulin with the nephrotoxic mechanism of certain petroleum-based Air Force fuels. Final report, 1 September 1984-31 August 1986

Technical Report · Fri Oct 31 04:00:00 EST 1986

OSTI ID:6927410

Eurell, T E

Fischer 344 male rats have a dose- and time-dependent proximal tubular degeneration induced by certain petroleum-based fuels. This degeneration may be associated with a low molecular weight alpha globulin (termed alpha-2U globulin). A new method was developed to obtain monospecific immunologic reagents for alpha-2U globulin using diafiltration, anion-exchange and hydroxylapatite chromatography. Rocket immunoelectrophoretic and isoelectric focusing techniques were developed to quantitatively and qualitatively assess changes in alpha-2U globulin after experimental exposure to hydrocarbon compounds.

• Research Organization: Illinois Univ., Urbana (USA). Dept. of Veterinary Biosciences
• OSTI ID: 6927410
• Report Number(s): AD-A-175104/9/XAB
• Country of Publication: United States
• Language: English

Related Subjects

02 PETROLEUM
020600 -- Petroleum-- Health & Safety
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CHROMATOGRAPHY
ELECTROPHORESIS
FILTRATION
FUELS
GLOBULINS
GLOBULINS-ALPHA
HYDROCARBONS
IMMUNOLOGY
ION EXCHANGE
KIDNEYS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
PETROLEUM PRODUCTS
PROTEINS
RATS
RODENTS
SEPARATION PROCESSES
TIME DEPENDENCE
TOXICITY
URINE
VERTEBRATES
WASTES