Comparative study regarding the association of alpha-2U globulin with the nephrotoxic mechanism of certain petroleum-based air force fuels. Final report 1, December 1987-30 November 1988

Technical Report · Thu Dec 01 04:00:00 EST 1988

OSTI ID:5559637

Eurell, T E

Fischer 344 male rats have a dose- and time-dependent renal proximal tubular degeneration induced by certain hydrocarbon compounds. This degeneration my be associated with a low-molecular-weight urinary protein called alpha-2U globulin. The authors using a rat-strain variation of the alpha-2U globulin molecule and metabolic alteration of the urinary pH as methods to investigate the hydrocarbon-induced nephrotoxic response. Two significant advances were made in the first year of this project: (1) a histochemical procedure was developed to specifically evaluate changes in the renal epithelial lysosome, and (2) a rat-strain difference was detected in susceptibility to hydrocarbon-induced nephrotoxicity.

• Research Organization: Illinois Univ., Urbana, IL (USA). Dept. of Veterinary Biosciences
• OSTI ID: 5559637
• Report Number(s): AD-A-205143/1/XAB
• Country of Publication: United States
• Language: English

Related Subjects

02 PETROLEUM
020900 -- Petroleum-- Environmental Aspects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
COMPARATIVE EVALUATIONS
DISEASES
DOCUMENT TYPES
FUELS
GLOBULINS
GLOBULINS-ALPHA
HISTOLOGY
HYDROCARBONS
JET ENGINE FUELS
KIDNEYS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
PETROLEUM PRODUCTS
PH VALUE
PROGRESS REPORT
PROTEINS
RATS
RODENTS
TOXICITY
URINE
UROGENITAL SYSTEM DISEASES
VERTEBRATES
WASTES