Comparative study regarding the association of alpha-2u globulin with the nephrotoxic mechanism of certain petroleum-based air force fuels. Annual report 1 Jul 90-30 Jun 91

Technical Report · Wed Aug 14 04:00:00 EDT 1991

OSTI ID:5996407

Eurell, T E

Adult male rats have a dose and time dependent renal proximal tubular degeneration induced by certain hydrocarbon compounds. This degeneration is associated with a low molecular weight urinary protein called alpha 2U globulin. We are using rat strain variation (Fisher 344 and NCI Black Reiter) and different hydrocarbon compounds (JP-4, JP-8, decalin and trimethylpentane) to investigate the hydrocarbon-induced nephrotoxic response. Preliminary histochemical and morphometric evaluation of NCI-Black Reiter rats exposed to JP-8 suggests that this strain undergoes an intermediate form of the hydrocarbon-induced nephrotoxicity when compared to the albino Fisher 344 strain.

• Research Organization: Illinois Univ., Urbana, IL (United States). Dept. of Veterinary Biosciences
• OSTI ID: 5996407
• Report Number(s): AD-A-240363/2/XAB; CNN: AFOSR-90-0303
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
FUELS
GLOBULINS
HYDROCARBONS
KIDNEYS
MAMMALS
METABOLISM
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PETROLEUM PRODUCTS
PROTEINS
RATS
RODENTS
SENSITIVITY
TOXICITY
TUBULES
VARIATIONS
VERTEBRATES