Comparative study regarding the association of alpha-2micro globulin with the nephrotoxic mechanism of certain petroleum-based Air Force fuels. Final report, 1 December 1987-30 June 1990

Technical Report · Mon Sep 17 04:00:00 EDT 1990

OSTI ID:6140078

Eurell, T E

Fisher 344 males rats have a dose and time-dependent renal proximal tubular degeneration induced by certain hydrocarbon compounds. We have used rat strain variation of the alpha-2micro globulin molecule and metabolic alteration of the urinary pH as methods to investigate the hydrocarbon-induced nephrotoxic response. Three significant advances have been made during this project: (1) the development of a histochemical procedure to specifically evaluate decalin-induced changes in the lysosomes of rat renal tubular epithelial cells, (2) the discovery that pigmented male rats demonstrate hydrocarbon-induced nephrotoxicity, and (3) the discovery of a difference in the hydrocarbon-induced nephrotoxicity response of male rats following alteration of the urinary pH. Sodium bicarbonate-induced elevation of the urinary pH markedly altered the lysosomal integrity and morphologic appearance of renal tubular cells in male rats exposed to decalin.

• Research Organization: Illinois Univ., Urbana, IL (USA). Coll. of Veterinary Medicine
• OSTI ID: 6140078
• Report Number(s): AD-A-228540/1/XAB; CNN: AFOSR-88-0033
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BODY
CELL CONSTITUENTS
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
ENERGY SOURCES
EPITHELIUM
FOSSIL FUELS
FUELS
GLOBULINS
HISTOLOGICAL TECHNIQUES
HYDROCARBONS
KIDNEYS
LYSOSOMES
MAMMALS
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PETROLEUM
PROGRESS REPORT
PROTEINS
RATS
RODENTS
SENSITIVITY
TIME DEPENDENCE
TISSUES
TOXICITY
VERTEBRATES