Contrasting effects of the stomach and small intestine of rats on copper absorption

Journal Article · Sat Nov 01 04:00:00 EST 1986 · J. Nutr.; (United States)

OSTI ID:6927083

Fields, M; Craft, N; Lewis, C; Holbrook, J; Rose, A; Reiser, S; Smith, J C

Since the severity of copper deficiency has been shown to be enhanced by feeding diets containing fructose but ameliorated by diets containing starch, we decided to investigate the effect of fructose or starch on copper absorption. As copper transport has been reported to occur also from the stomach, it was possible that copper absorption is inhibited by fructose already from that tissue. Under anesthesia, stomachs of 72 rats fed copper-deficient or supplemented diets containing fructose or starch were ligated prior to the oral administration of /sup 64/Cu. Gastric absorption of /sup 64/Cu was studied when the isotope was administered by gastric tube either in diet containing fructose or starch or in water. /sup 64/Cu was not absorbed from the stomach regardless of the type of dietary treatment, copper status or whether the copper was administered either in diet or in water. In addition, the absorption of /sup 64/Cu from a diet containing either fructose or starch or from a saline solution was studied using the isolated ligated duodenal loop. When /sup 64/Cu was administered with dietary fructose /sup 64/Cu retention and absorption were impaired when compared to starch. When /sup 64/Cu was administered in saline solution, differences in retention and absorption between the four dietary groups disappeared. It is suggested that the requirements for copper rather than the decreased absorption of copper are responsible at least in part for the more pronounced severity of copper deficiency in rats fed fructose compared to those fed starch.

• Research Organization: Georgetown Univ., Washington, DC
• OSTI ID: 6927083
• Journal Information: J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 11; ISSN JONUA
• Country of Publication: United States
• Language: English

Related Subjects

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560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARBOHYDRATES
COPPER
COPPER 64
COPPER ISOTOPES
DIET
DIGESTIVE SYSTEM
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
FRUCTOSE
GASTROINTESTINAL TRACT
HEXOSES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
MAMMALS
METALS
MONOSACCHARIDES
NUCLEI
NUTRITIONAL DEFICIENCY
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
RADIOISOTOPES
RATS
REAGENTS
RETENTION
RODENTS
SACCHARIDES
STARCH
STOMACH
TRACER TECHNIQUES
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES