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Tissue distribution and excretion of copper-67 intraperitoneally administered to rats fed fructose or starch

Journal Article · · J. Nutr.; (United States)
OSTI ID:5429206
; ; ;
It has been suggested that impaired gut absorption of copper is the cause of the exacerbated copper deficiency signs in rats fed fructose when compared to rats fed starch. The present study was designed to examine how rats fed fructose or starch diets, either copper-deficient or supplemented, distributed and excreted /sup 67/Cu when the isotope was administered i.p. Intraperitoneal administration was chosen in an effort to circumvent primary gut absorption as a factor in the metabolism of /sup 67/Cu. After 7 wk of dietary treatment, rats received an i.p. injection of /sup 67/Cu and were placed in metabolic cages for 4 d. Regardless of dietary carbohydrate, copper-deficient rats retained similar levels of radioactivity in various tissues and excreted similar amounts of /sup 67/Cu in feces and urine. This similarity in copper metabolism in copper-deficient rats fed either fructose or starch when the gut was circumvented for isotope administration suggests that the gut could be responsible, at least in part, for the exacerbated signs associated with the copper deficiency in rats fed fructose. The possibility is discussed that alterations in metabolism may increase the requirement for copper when fructose is the main dietary carbohydrate.
Research Organization:
Beltsville Human Nutrition Research Center, MD
OSTI ID:
5429206
Journal Information:
J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 5; ISSN JONUA
Country of Publication:
United States
Language:
English

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Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARBOHYDRATES
CLEARANCE
COPPER
COPPER 67
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DIET
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
EXCRETION
FECES
FRUCTOSE
GLANDS
HEXOSES
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
ISOTOPES
KETONES
LIVER
MAMMALS
MATERIALS
METABOLISM
METALS
MONOSACCHARIDES
NUCLEI
NUTRITIONAL DEFICIENCY
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
RADIOISOTOPES
RATS
REAGENTS
RODENTS
SACCHARIDES
STARCH
TISSUE DISTRIBUTION
TRANSITION ELEMENTS
UPTAKE
URINE
VERTEBRATES
WASTES