Effect of fructose or starch on copper-67 absorption and excretion by the rat

Journal Article · Tue Apr 01 04:00:00 EST 1986 · J. Nutr.; (United States)

OSTI ID:5591499

Fields, M; Holbrook, J; Scholfield, D; Smith, Jr, J C; Reiser, S

Studies with /sup 67/Cu were conducted with copper-deficient or supplemented rats fed fructose or starch in an effort to investigate the effects of different dietary carbohydrates and inadequate copper intake on the absorption, tissue distribution and excretion of copper. After being fed their diets for 5 wk, they were killed at 8, 24, 48 and 96 h following the intubation of their respective copper-supplemented diets extrinsically labeled with /sup 67/Cu. Only at 48 and 96 h following the intubation of /sup 67/Cu, the gastrointestinal (GI) contents of rats fed the copper-deficient fructose diet exhibited higher radioactivity than rats fed the copper-deficient starch diet. Although not always significant, this apparent retention of copper in GI contents was accompanied by decreased whole-body radioactivity and depressed urinary excretion. The cumulative excretion of /sup 67/Cu via feces over the 96-h period of collection was similar for both groups of copper-deficient rats, regardless of whether the dietary carbohydrate was fructose or starch. The data suggest that the more severe copper deficiency is related to the sustained higher level of radioactivity in the GI contents. This increased retention of /sup 67/Cu in GI contents suggests impaired absorption of copper.

• Research Organization: Georgetown Univ. Medical School, Washington, DC
• OSTI ID: 5591499
• Journal Information: J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 4; ISSN JONUA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
CARBOHYDRATES
CLEARANCE
COPPER
COPPER 67
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
EXCRETION
FECES
FRUCTOSE
GLANDS
HEXOSES
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
ISOTOPES
KETONES
LIVER
MAMMALS
MATERIALS
METALS
MONOSACCHARIDES
NUCLEI
NUTRITIONAL DEFICIENCY
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
RADIOISOTOPES
RATS
REAGENTS
RETENTION
RODENTS
SACCHARIDES
STARCH
TISSUE DISTRIBUTION
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES
WASTES