Tissue sorbitol concentration can be altered by changing the type of dietary carbohydrate or copper status

Journal Article · Thu Feb 09 04:00:00 EST 1989 · FASEB Journal (Federation of American Societies for Experimental Biology); (USA)

OSTI ID:6832856

Beal, T; Lewis, C G; Fields, M ^[1]

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1. Univ. of Maryland, College Park (USA)

This study was designed to determine whether rehabilitation of tissue sorbitol concentration occurs when rats consuming a high-fructose, low-copper diet are changed to diets containing starch or copper. Weanling male rats were provided with a diet which contained 62.7% fructose and 0.6 or 6.0 {mu}g Cu/g (F-Cu) for 4 weeks and then changed to either a fructose diet which contained 6.0 {mu}g Cu/g or a starch diet which contained either 0.6 or 6.0 {mu}g Cu/g for 2 weeks. Hepatic copper concentration of rats eating copper-deficient diets was about 30% of copper adequate rats regardless of the type of dietary carbohydrate. Pancreatic fructose, glucose and sorbitol concentrations were significantly lowered in rats changed to a starch diet. Kidney fructose and sorbitol concentrations were significantly lowered in rats changed to a starch diet. For all dietary groups, pancreatic and kidney sorbitol concentrations returned to normal after removal of rats from the F-Cu diet. In general, changing rats from a high-fructose, low-copper diet to a fructose diet with copper or a starch diet with or without copper improved the copper deficiency symptoms which changed in concert with tissue sorbitol levels.

• OSTI ID: 6832856
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (USA), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (USA) Vol. 3:3; ISSN FAJOE; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBOHYDRATES
COPPER
DIET
DIGESTIVE SYSTEM
DIURETICS
DRUGS
ELEMENTS
ENDOCRINE GLANDS
FRUCTOSE
GLANDS
GLUCOSE
HEXOSES
KETONES
KIDNEYS
LIVER
MAMMALS
METABOLISM
METALS
MONOSACCHARIDES
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANS
PANCREAS
POLYSACCHARIDES
RATS
REAGENTS
RODENTS
SACCHARIDES
SORBITOL
STARCH
TRANSITION ELEMENTS
VERTEBRATES