Sorbitol accumulation in male and female rats consuming starch or fructose diets with or without copper

Journal Article · Thu Feb 09 04:00:00 EST 1989 · FASEB Journal (Federation of American Societies for Experimental Biology); (USA)

OSTI ID:6905910

Lewis, C G; Fields, M; Beal, T ^[1]

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1. Dept. of Agriculture, Beltsville, MD (USA)

The present study was designed to examine the relationship between the sex of the rats, tissue sorbitol accumulation and copper deficiency in rats consuming dietary fructose. Rats were provided with a diet containing either 62.7% fructose or starch, and either 6.0 or 0.6 {mu}g copper/g for three weeks. Hepatic copper concentration of all rats consuming the copper-deficient diets was about 40% of copper sufficient rats. Hepatic, renal and thymic sorbitol concentrations were significantly elevated in males consuming the fructose, copper-deficient diet when compared to all other dietary groups regardless of the sex of the rat. Hepatic, renal the thymic fructose concentrations were significantly higher in rats eating fructose as compared to female rats. Hepatic glucose concentration was higher in males and females consuming the fructose, copper-deficient diet when compared to all other dietary groups. Renal glucose concentration was elevated in males as compared to females. These results demonstrate that the pathology and complications of copper deficiency in the male rat consuming fructose closely parallel aberration in tissue sorbitol accumulation.

• OSTI ID: 6905910
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (USA), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (USA) Vol. 3:3; ISSN FAJOE; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
CARBOHYDRATES
COPPER
DIURETICS
DRUGS
ELEMENTS
FEMALES
FRUCTOSE
HEXOSES
KETONES
KINETICS
MALES
MAMMALS
METALS
MONOSACCHARIDES
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
POLYSACCHARIDES
RATS
REACTION KINETICS
REAGENTS
RODENTS
SACCHARIDES
SORBITOL
STARCH
TRANSITION ELEMENTS
VERTEBRATES