Female rates are protected against the fructose induced mortality of copper deficiency

Journal Article · Wed Oct 01 04:00:00 EDT 1986 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-183-1-RC2· OSTI ID:6914156

Fields, M; Lewis, C; Scholfield, D J; Powell, A S; Rose, A J; Reiser, S; Smith, J C

Experiments were conducted in copper deficient male and female rats fed diets containing fructose or starch in order to determine whether the same type of interaction between copper status and dietary carbohydrate found in male rats also occurs in the female rat. Mortality occurred only in the male rats fed the fructose diet deficient in copper with 40% of the animals dying during the 8 week study. Only anemia, hypercholesterolemia, increased BUN, heart hypertrophy and reduced body weight were observed in these animals which could be related to their mortality. Despite the increased mortality, plasma ceruloplasmin, erythrocyte SOD and hepatic copper concentrations were reduced to a similar extent in all rats regardless of the sex of the animals or of the type of dietary carbohydrate fed. The results of the present study indicate that although direct measurements of copper status of female rats fed fructose diet deficient in copper are similar to their male counterpart, they are apparently protected from the lethal consequences of the deficiency.

• Research Organization: Dept. of Agriculture, Beltsville, MD
• OSTI ID: 6914156
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 183:1; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
ANIMALS
BLOOD CHEMISTRY
BODY
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
COPPER
DATA
DIET
DIGESTIVE SYSTEM
DISEASES
ELEMENTS
EXPERIMENTAL DATA
FRUCTOSE
GLANDS
HEART
HEMIC DISEASES
HEXOSES
INFORMATION
KETONES
LIVER
MALES
MAMMALS
METALS
MONOSACCHARIDES
MORTALITY
NUMERICAL DATA
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SACCHARIDES
SENSITIVITY
SEX DEPENDENCE
SYMPTOMS
TRANSITION ELEMENTS
VERTEBRATES
WEIGHT