Toxicity of mycotoxins for the rat pulmonary macrophage in vitro

Journal Article · Tue Apr 01 00:00:00 EST 1986 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.866645· OSTI ID:6915826

Sorenson, W G; Gerberick, G F; Lewis, D M; Castranova, V

The presence of mycotoxins in grains is well documented. Workers in grain handling occupations are commonly exposed to grain dust aerosols. Work in our laboratory has shown that T-2 toxin is highly toxic to rat alveolar macrophages in vitro, causing loss of viability, release of radiolabeled chromium, inhibition of macromolecular synthesis, inhibition of phagocytosis, and inhibition of macrophage activation. Similarly, patulin caused a significant release of radiolabeled chromium, decrease in ATP levels, significant inhibition of protein and RNA synthesis, and inhibition of phagocytosis. The data show that both T-2 toxin and patulin are highly toxic to rat alveolar macrophages in vitro. The data further suggest that the presence of these mycotoxins in airborne respirable dust might present a hazard to exposed workers.

• Research Organization: National Institute for Occupational Safety and Health, Morgantown, WV
• OSTI ID: 6915826
• Journal Information: Environ. Health Perspect.; (United States), Vol. 66
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MACROPHAGES
RADIOASSAY
TOXINS
BIOLOGICAL EFFECTS
CEREALS
CHROMIUM 51
FUNGI
IN VITRO
LUNGS
PERSONNEL
RATS
SEEDS
ANIMAL CELLS
ANIMALS
ANTIGENS
BETA DECAY RADIOISOTOPES
BODY
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GRASS
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MATERIALS
NUCLEI
ORGANS
PHAGOCYTES
PLANTS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
TOXIC MATERIALS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560300 - Chemicals Metabolism & Toxicology