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Thermal enhancement of radiosensitivity in normal and ataxia telangiectasia human cells

Journal Article · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
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Normal human and ataxia telangiectasia (AT) fibroblasts were tested for enhancement of radiosensitivity by hyperthermia. In normal fibroblasts, thermal enhancement of radiosensitivity occurred at 42.0/sup 0/ and 45.0/sup 0/C and was greatest for simultaneous treatments of heat and radiation. This thermal enhancement decreased, as an incubation time at 37.0/sup 0/C was introduced either between heat and X-ray, or X-ray and heat, treatments. AT cells were more radiosensitive (D/sub 0/=0.67 Gy) than normal cells (D/sub 0/=1.4 Gy). Heating at 42.0/sup 0/ or 45.0/sup 0/C resulted in enhanced radiosensitivity, which was equal for heating before, during or after irradiation. These data show that normal human fibroblasts can recover from heat and radiation treatments, while AT fibroblasts lack this ability.
Research Organization:
Whiteshell Nuclear Research Establishment, Pinawa, Manitoba, Canada
OSTI ID:
6915270
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:2; ISSN IOBPD
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560201 -- Thermal Effects-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY TEMPERATURE
CELL KILLING
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
FIBROBLASTS
HYPERTHERMIA
IONIZING RADIATIONS
MAMMALS
MAN
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RECOVERY
SKIN DISEASES
SOMATIC CELLS
SURVIVAL CURVES
TELANGIECTASIS
VASCULAR DISEASES
VERTEBRATES
X RADIATION