Hyperthermia enhances X ray cell killing in normal and homozygous and heterozygous ataxia telangiectasia human cells

Journal Article · Mon Apr 01 04:00:00 EST 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(85)90321-9· OSTI ID:5415207

Raaphorst, G P; Azzam, E I

Two homozygous and heterozygous ataxia telangiectasia (AT) cell strains were compared to normal human cells for heat and radiation responses. The thermal sensitivities to one hour heating at 42.0 degrees C were comparable in the five cell strains. Thermal enhancement of radiosensitivity occurred in both homo- and hetero-zygous AT cell strains and was comparable to the thermal enhancement observed in the normal cell strain. Normal cells recovered during incubation at 37.0 degrees C between the two treatments of heat and X rays while homozygous AT cells showed no recovery. The heterozygous cell strains showed only a slight sequence dependence for heat and radiation sensitivity.

• Research Organization: Atomic Energy of Canada Limited Research Co., Pinawa, Manitoba
• OSTI ID: 5415207
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:4; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
BODY TEMPERATURE
CELL CULTURES
CELL KILLING
COMPARATIVE EVALUATIONS
ELECTROMAGNETIC RADIATION
ENDOTHELIUM
ENERGY
HEAT
HYPERTHERMIA
IONIZING RADIATIONS
MAMMALS
MAN
PRIMATES
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
TISSUES
VERTEBRATES
X RADIATION