The thermal sensitivity of normal and ataxia telangiectasia human fibroblasts

Journal Article · Mon Nov 01 04:00:00 EST 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90454-0· OSTI ID:5238396

Raaphorst, G P; Azzam, E I

Human normal and ataxia telangiectasia (AT) heterozygote and homozygote cell strains were heated at 42.0 and 45.0/sup 0/C to determine their thermal responses. All cell strains had approximately the same thermal sensitivity and were less thermally sensitive than Chinese hamster cells or many other rodent cell lines reported in the literature. No shoulders were observed on the survival curves for heating at 42.0 or 45.0/sup 0/C. Thermal tolerance developed in both the normal and AT cells strains with heating for prolonged intervals at 42.0GAMMA.

• Research Organization: Whiteshell Nuclear Research Establishment, Pinawa, Manitoba, Canada
• OSTI ID: 5238396
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:11; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560201* -- Thermal Effects-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BODY
BODY TEMPERATURE
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBELLUM
CHO CELLS
CONNECTIVE TISSUE CELLS
DISEASES
FIBROBLASTS
HYPERTHERMIA
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
ORGANS
SOMATIC CELLS
SURVIVAL CURVES
TEMPERATURE EFFECTS
TOLERANCE