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Hyperthermia and thermal tolerance in normal and ataxia telangiectasia human cell strains

Journal Article · · Cancer Res.; (United States)
OSTI ID:5982963
;
Three normal human fibroblast strains, two human ataxia telangiectasia heterozygote cell strains, and two human ataxia telangiectasia homozygote cell strains were studied for their thermal responses between 41.0 and 46.0/sup 0/. The heat sensitivities of all cell strains were comparable, and all cell strains were relatively heat resistant compared to Chinese hamster cells. Both normal and ataxia telangiectasia human cells developed thermal tolerance during heating at temperatures less than or equal to 43/sup 0/ and during incubation at 37/sup 0/ after acute heating at 45.0/sup 0/. For survival measured down to the 5 to 10% level, heat survival curves for all seven human cell strains lacked shoulders, indicating the inability of such cells to accumulate sublethal heat damage. Analysis of the cell survival curve data by the method of Arrhenius showed that the thermal inactivation energies for human cells were 127 and 230 kcal/mol above and below the break at 43.5/sup 0/, respectively, and are about the same as for Chinese hamster cells and other animal cells, implying similar mechanisms of heat inactivation. Patients with AT are very radiosensitive, making radiotherapy in such patients difficult. Hyperthermia may provide an alternate means for cancer therapy in such patients.
Research Organization:
Atomic Energy of Canada Research Co., Pinawa, Manitoba
OSTI ID:
5982963
Journal Information:
Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 43; ISSN CNREA
Country of Publication:
United States
Language:
English

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Related Subjects

560201* -- Thermal Effects-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL VARIABILITY
BODY TEMPERATURE
CELL CULTURES
CHO CELLS
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DISEASES
FIBROBLASTS
GENETIC VARIABILITY
HEREDITARY DISEASES
HYPERTHERMIA
INACTIVATION
INJURIES
MAMMALS
MAN
PRIMATES
RADIOSENSITIVITY
SENSITIVITY
SOMATIC CELLS
SURVIVAL CURVES
THERAPY
TOLERANCE
VERTEBRATES