The thermal sensitivity of normal and ataxia telangiectasia human fibroblasts

Journal Article · Fri Jan 01 04:00:00 EST 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90454-0· OSTI ID:5344564

Raaphorst, G P; Azzam, E I

Human normal and ataxia telangiectasia (AT) heterozygote and homozygote cell strains were heated at 42.0 and 45.0/sup 0/C to determine their thermal responses. All cell strains had approximately the same thermal sensitivity and were less thermally sensitive than Chinese hamster cells or many other rodent cell lines reported in the literature. No shoulders were observed on the survival curves for heating at 42.0 or 45.0/sup 0/C. Thermal tolerance developed in both the normal and AT cell strains with heating for prolonged intervals at 42.0/sup 0/C.

• Research Organization: Atomic Energy of Canada, Ltd., Pinawa, Manitoba
• OSTI ID: 5344564
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560201* -- Thermal Effects-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BODY TEMPERATURE
CONNECTIVE TISSUE CELLS
FIBROBLASTS
HAMSTERS
HUMAN POPULATIONS
HYPERTHERMIA
MAMMALS
POPULATIONS
RODENTS
SENSITIVITY
SOMATIC CELLS
STRESSES
TEMPERATURE EFFECTS
THERMAL STRESSES
VERTEBRATES