Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent

Journal Article · · Am. J. Roentgenol.; (United States)
; ; ;

Chelation of the rare-earth element gadolinium (Gd) with diethylenetriaminepentaacetic acid (DTPA) results in a strongly paramagnetic, stable complex that is well tolerated in animals. The strongly paramagnetic gadolinium complex reduces hydrogen-proton relaxation times even in low concentrations (less than 0.01 mmol/L). The pharmacokinetic behavior of intravenously delivered Gd-DTPA is similar to the well known iodinated contrast agents used in urography and angiography; excretion is predominately through the kidneys with greater than 90% recovery in 24 hr. The intravenous LD/sub 50/ of the meglumine salt of Gd-DTPA is 10 mmol/kg for the rat; in vivo there is no evidence of dissociation of the gadolinium ion from the DTPA ligand. The combination of strong proton relaxation, in-vivo stability, rapid urinary excretion, and high tolerance favors the further development and the potential clinical application of gadolinium-DTPA as a contrast enhancer in magnetic resonance imaging.

Research Organization:
Schering AG, Berlin, West Germany
OSTI ID:
6914697
Journal Information:
Am. J. Roentgenol.; (United States), Journal Name: Am. J. Roentgenol.; (United States) Vol. 142:3; ISSN AJROA
Country of Publication:
United States
Language:
English

Similar Records

Contrast-enhanced NMR imaging: animal studies using gadolinium-DTPA complex
Journal Article · Wed Feb 29 23:00:00 EST 1984 · Am. J. Roentgenol.; (United States) · OSTI ID:6916387
Gadolinium-phthalein complexone as a contrast agent for hepatobiliary MR imaging
Journal Article · Sat Dec 31 23:00:00 EST 1988 · J. Comput. Assist. Tomogr.; (United States) · OSTI ID:6499835
Tissue distribution and magnetic resonance spin lattice relaxation effects of gadolinium-DTPA
Conference · Thu Feb 28 23:00:00 EST 1985 · Radiology; (United States) · OSTI ID:5650823

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560171 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CHLORIDES
CHLORINE COMPOUNDS
CONTRAST MEDIA
DAYS LIVING RADIOISOTOPES
DOSES
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GADOLINIUM 153
GADOLINIUM CHLORIDES
GADOLINIUM COMPOUNDS
GADOLINIUM ISOTOPES
HALIDES
HALOGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
KIDNEYS
LETHAL DOSES
MAGNETIC RESONANCE
MAMMALS
NUCLEAR MAGNETIC RESONANCE
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHARMACOLOGY
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
RARE EARTH COMPOUNDS
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RATS
RESONANCE
RODENTS
VERTEBRATES