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Contrast-enhanced NMR imaging: animal studies using gadolinium-DTPA complex

Journal Article · · Am. J. Roentgenol.; (United States)
; ;

Gadolinium (Gd)-DTPA complex was assessed as a nuclear magnetic resonance (NMR) contrast-enhancing agent by experimentally imaging normal and diseased animals. After intravenous injection, Gd-DTPA, a strongly paramagnetic complex by virtue of unpaired electrons, was rapidly excreted into the urine of rats, producing an easily observable contrast enhancement on NMR images in kidney parenchyma and urine. Sterile soft-tissue abscesses demonstrated an obvious rim pattern of enhancement. A focus of radiation-induced brain damage in a canine model was only faintly detectable on spin-echo NMR images before contrast administration; after 0.5 mmol/kg Gd-DTPA administration, the lesion intensity increased from 3867 to 5590. In comparison, the normal brain with an intact blood-brain barrier remained unchanged in NMR characterization. Gd-DTPA is a promising new NMR contrast enhancer for the clinical assessment of renal function, of inflammatory lesions, and of focal disruption of the blood-brain barrier.

Research Organization:
Univ. of California, San Francisco
OSTI ID:
6916387
Journal Information:
Am. J. Roentgenol.; (United States), Journal Name: Am. J. Roentgenol.; (United States) Vol. 142:3; ISSN AJROA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSCESSES
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BLOOD-BRAIN BARRIER
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
CLEARANCE
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DOGS
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
GADOLINIUM 153
GADOLINIUM ISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOTOPES
KIDNEYS
MAGNETIC RESONANCE
MAMMALS
NERVOUS SYSTEM
NUCLEAR MAGNETIC RESONANCE
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RATS
RESONANCE
RODENTS
SPIN ECHO
VERTEBRATES